doi:10.1136/jnnp.2007.133025
In these studies, fetal malformations (primarily craniofacial defects such as cleft palate), limb malformations (ectrodactyly, micromelia, and amelia), rib/vertebral column anomalies, and/or reduced fetal weights were observed at dosages 20 mg/kg in mice (approximately 2 times the MRHD of topiramate in QSYMIA 15 mg/92 mg on a mg/m 2 basis), 20 mg/kg in rats (2 times the MRHD of QSYMIA based on estimated AUC), and 35 mg/kg in rabbits (2 times the MRHD based on estimated AUC)
Taurine inhibits neuronal excitability through interaction with presynaptic glutamatergic receptors (NMDA) and GABA A receptors (positive allosteric modulator of 2 subunit of GABA A receptor) (Tarragon et al., 2021)
The transcription factor NRF2 protects against pulmonary fibrosis
The agency flagged claims about generic or clinically proven versions of approved GLP-1 therapies as potentially misbranded advertising in violation of the FDCA
National Library of Medicine, Accessed 20 Aug