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Arbutin : A naturally occurring compound derived from bearberry and other plants, Arbutin is known for its ability to inhibit tyrosinase, the enzyme critical for melanin production

Therefore, the underlying mechanism of development of NERD is indisputably different from that of RE (9, 10)

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First, the vast majority of available data derives from animal studies, and extrapolation to human applications may not be straightforward due to species differences in physiology and drug metabolism

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