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Through his research, Dr Sinclair has identified key pathways and molecules that influence the ageing process, challenging conventional wisdom and offering hope for extending not just lifespan, but more importantly, "healthspan" the period of life spent in good health

The gut microbiome can also play a significant role in how conjugated toxins are moved out through feces or absorbed back into the body.[ref] ABCB1 P-gp efflux transporter for medications, HRT, and environmental toxins SLCO1B1 and ABCG2 statins and muscle pain risk OCTN1 organic cation transporter, ergothionine Detoxification pathways for specific substances: In addition to the phase I and phase II specific genes above, the following articles look at specific toxicants and their detoxification pathways: Mold Genes Arsenic Detoxification BPA Detoxification Glyphosate Detoxification Organophosphate Pesticides Caffeine Metabolism Phthalate Detoxification Lead PFAS Fluoride DPYD 5-fluorouracil toxicity Mercury Molybdenum and copper ALDH2, ADH1B and Alcohol By learning about your genetic variants and their impact on detoxification pathways, you can take proactive steps to support your bodys natural ability to eliminate harmful substances and maintain optimal health

Bioavailability refers to the amount of a nutrient that actually enters your circulation and is used by your body

Moreover, evidence has emerged that a link exists between glutathione (GSH) metabolism and the epigenetic regulation of redox phenomena 3,4

Interactions between the microbiota, immune and nervous systems in health and disease