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Circulation 140 , 225239 (2019)

By stimulating GLP-1 receptors in the body, semaglutide amplifies these effects, leading to improved blood sugar control and reduced hunger

On the other hand, it has been shown that pro-inflammatory and oxidative stimuli in diseased vessels and/or the myocardium can modify adipose tissue biology, suggesting a bidirectional crosstalk between the adipose tissue and the cardiovascular system [67, 68]

it's neurobiology

There is evidence to suggest that mutations in the MAGEL2 gene may contribute to the characteristic weight gain seen in individuals with PWS

At that point, 19 cases of the condition had been reported