The authors administered oral Dihexa to APP/PS1 transgenic mice (a standard amyloidopathy model of Alzheimers disease) and showed that brain AngIV levels were elevated relative to wild-type after Dihexa administration, that spatial learning and memory were restored on Morris water maze testing, that hippocampal neuronal density and synaptophysin protein expression were preserved, that astrocyte and microglial activation were reduced, and that pro-inflammatory cytokines (IL-1, TNF-) decreased while anti-inflammatory IL-10 increased
[DOI] [PubMed] [Google Scholar] 41.Evans MD, Cooke MS, Akil M, Samanta A, Lunec J
Once released, GLP-1 helps the body to: Stimulate insulin release when blood glucose rises Reduce glucagon secretion, which helps prevent blood sugar spikes Slow gastric emptying, keeping food in the stomach for longer Increase feelings of fullness and reduce appetite These are important processes for metabolic health and energy balance
The majority of events were reported as diabetic retinopathy (4%, 2.7%, and 2.7%, respectively) and non-proliferative retinopathy (0.7%, 0%, and 0%, respectively)
The study established the extracellular matrix remodeling profile of GHK-Cu [2]
Studies with 7 stars were rated as high-quality studies
