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Regarding cardiac risk, the lorcaserin group was non-inferior to the placebo group with slightly better values in cardiac risk factors (blood pressure, heart rate, glycemic control, lipid profile)

Phase 1b PoC fully enrolled APG273APG273 / IL-13 + TSLP / combination of zumilokibart (APG777) + APG333 monoclonal antibodies / respiratory immunology and inflammationAsthma / COPDPreclinicalin-progress APG808APG808 / IL-4R / antibody / respiratory immunology and inflammationAsthmaPhase 1bpositive interim results announced May 2025 4assets BPL-003BPL-003 / Intranasal mebufotenin benzoate / Mental healthTreatment-resistant depressionPhase 2In development VLS-01VLS-01 / 5-HT1/2/6/7 receptor agonist / Oral transmucosal DMT buccal film / Mental healthTreatment-resistant depressionPhase 2In development EMP-01EMP-01 / Oral R-MDMA / Mental healthSocial anxiety disorderPhase 2Positive topline results announced Novel 5-HT2A Receptor Agonists5-HT2A receptor / Small-molecule neuroplastogens / Mental healthOpioid use disorderDiscoveryIn developmentTreatment-resistant depressionDiscoveryIn development 4assets DeramiocelCAP-1002 / allogeneic CDCs / Neuromuscular diseaseDuchenne muscular dystrophy (DMD)Phase 3in progressBecker muscular dystrophy (BMD)Preclinicalin progress StealthXSTX-S / Exosome-based vaccine / Infectious diseaseSARS-CoV-2Phase 1in progress StealthXTherapeutic ExosomesEvaluatingPreclinicalin progress CDC-ExosomesExosome Platform / Neuromuscular diseaseDuchenne muscular dystrophyPreclinicalin progress 4assets CLN-978CLN-978 / CD19xCD3 / bispecific T cell engager / ImmunologyOUTRACE: Rheumatoid arthritisPhase 1Initial data in RA in Q2 2026 and repeat dosing data in Q3 2026EuropeOUTRACE: Systemic lupus erythematosusPhase 1bInitial data in SLE in Q2 2026GlobalOUTRACE: Sjgrens diseasePhase 1Initial data in Sjgrens disease in Q4 2026Global VelinotamigBCMAxCD3 / bispecific T cell engager / ImmunologyAutoimmune diseasesIND-EnablingGenrix Bio initiated a Phase 1 study in China in Q4 2025

Mild, transient effects during the first two weeks typically do not require intervention beyond patience

Patients generally respond positively when providers acknowledge the financial and access barriers that influenced their choices

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Alberti KG, Johnston DG, Gill A, et al