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Deficiency can develop gradually over years, as the liver stores significant amounts of B12typically enough to last 24 years

Blood 120(19):41044115 Phng LK et al (2009) Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis

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Changes in markers, pathways, or models do not automatically establish reduced swelling, less discomfort, better healing, improved function, or faster recovery in humans

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Pace BS et al