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Sources NIH: Topical Hydroquinone for Hyperpigmentation: A Narrative Review ScienceDirect: The Use of Botanical Extracts as Topical Skin-Lightening Agents for the Improvement of Skin Pigmentation Disorders JAAD: 51716 Hydroquinone and Alternative Agents for Hyperpigmentation: A Systematic Review

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IV injections work throughout the body, and topical serums specifically target pigmentation at the surface of the skin and carry less systemic danger