Phase 3 trial data documented 28.7% average weight loss with retatrutide 12mg versus 14.9% with semaglutide 2.4mg, though these come from different trials with different populations
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Understanding these properties helps explain why 4 weeks works as the standard escalation interval
Nausea, vomiting, diarrhea, constipation, and abdominal discomfort are commonly monitored in this drug class, but the exact approved safety profile for retatrutide is not established
For cagrilintide , the most significant trial programme involves its combination with semaglutide (CagriSema), investigated in the REDEFINE trial series
Frequently Asked Questions Can retatrutide affect fertility in women