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Centanni M, Duntas L, Feldt-Rasmussen U, Koehrle J, Peeters RP, Razvi S et al (2025) ETA guidelines for the use of levothyroxine sodium preparations in monotherapy to optimize the treatment of hypothyroidism

The other is it can break down in stomach acid, requiring the body to put it back together (which is nutrient intensive)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Woo S-H, Mo YJ, Lee Y-I, Park JH, Hwang D, Park TJ, Kang HY, Park SC, Lee Y-S