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But with a delay in the restrictions taking effect, the costs still weighed on the insurers income statement this past year, with Point32 spending $180 million on GLP-1s for weight loss alone

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What the structural changes do quantitatively: Published binding studies originating from GroPep research that produced the original analog show that the LR3 modifications reduce affinity for IGFBP-3 by a very large margin (multiple orders of magnitude) compared to native IGF-1

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