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Effect of Antidepressants on the Glutamatergic and GABAergic Systems Antidepressants are categorized into different classes: selective serotonin reuptake inhibitors, serotoninnorepinephrine reuptake inhibitors, and selective norepinephrine reuptake inhibitors, which increase the level of synaptic monoamine neurotransmitters by blocking their reuptake in neurons

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