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Other GHRH analog peptides, such as sermorelin, have also been reported to increase lean mass in healthy individuals [16]

Notably, this effect appeared in participants with no history of binge eating, suggesting the drug's satiety effect is primary, not secondary to behavioral change

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[1] [2] However, retatrutide has not yet received approval from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA), and it does not hold a UK marketing authorisation

The same applies if constipation keeps returning after every dose increase, requires frequent laxatives, or comes with new weight-loss medication side effects you cannot explain