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Beyond obesity and weight-loss maintenance, ROSE-010 has also shown clinically meaningful, statistically significant pain relief in a separate Phase 2a study of patients with irritable bowel syndrome (IBS), supporting its potential as the first targeted, on-demand therapy for acute IBS pain

International Journal of Cosmetic Science 27(3):155-160. [doi.org]

The changes are most noticeable in areas with higher beta-3 adrenergic receptor density: the lower abdomen, flanks, and visceral fat compartments

Are they safe

Polymenis M, ed

When the container is three-quarters full, seal it and dispose according to local regulations