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Contraindicated in patients with a personal or family history of MTC and in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2)

In the liver, the accumulation of ammonia can lead to inflammation, stellate cell activation, and fibrogenesis, which may contribute to the progression of fatty liver disease to more severe stages, such as cirrhosis and hepatocellular carcinoma

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The coverage outcome depends on a single fact: whether coverage came through a large employer or the ACA marketplace

It is well established that multiple GLP-1RA treatments increase levels of blood pancreatic enzymes (amylase, lipase) as measured by laboratory assay, including in the STEP 1 trial 20