A high-glucose environment affects islet cells and mitochondrial quality control in the nervous system, cardiovascular system, urinary system cells and gradually causes common complications such as diabetic peripheral neuropathy, diabetic cardiomyopathy and diabetic nephropathy
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Tryptophan derivatives regulate the transcription of Oct4 in stem-like cancer cells
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It impairs BBB permeability by inducing the degradation of tight junction proteins (e.g., occludin, claudin-5), thereby exacerbating neuroinflammation (Vezzani and Baram, 2007
