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Semaglutide should not be used in individuals with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2)

doi: 10.1139/v05-181

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If menstrual changes are particularly troublesome, discussing the rate of weight loss with your healthcare provider may be appropriate

Muscle cramps are not listed as a common side effect in FDA labeling for GLP-1 receptor agonists, and clinical trials have not shown significantly higher rates compared to placebo