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Congenital defects in any of the 15 genes that are involved in trafficking and metabolism of vitamin B-12 also cause vitamin B-12 deficiency, as does chronic exposure to nitrous oxide (2)

Eisenberg M, Deboever N, Hofstetter WL, Mehran RJ, Rice DC, Rajaram R, Swisher SG , Vaporciyan AA, Walsh GL, Antonoff MB

553 Additionally, the deubiquitinating enzyme USP14, which regulates proteasome activity, modulates autophagy by controlling the levels of ubiquitinated proteins

We can also prescribe medicine to help if you feel anxious or depressed

Weeks 4-8: Finding Your Rhythm Adjusting doses and meals : Your clinician may gradually increase your dose during this period to maximize benefits while keeping side effects manageable

doi: 10.1007/s12029-021-00587-0