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Semaglutide pens and vials must stay cold to preserve their chemical structure, but research shows they can remain stable at room temperature for limited periods under specific conditions

Additional comparative evidence comes from: A 2025 narrative review synthesising randomised and indirect comparison data across obesity and type 2 diabetes trials, confirming tirzepatides superiority on weight and HbA1c [2]

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Subcutaneous tissue has fewer pain receptors than muscle or skin, which is why these injections are generally well-tolerated

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