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IGF-1 Increase Once GH enters the bloodstream, the liver makes more IGF-1 (insulin-like growth factor 1)

P., Lindegaard, M

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Indeed, it is well documented that regular consumption of high-glycemic index meals, compared to isoenergetic meals with the same carbohydrate content, results in higher average 24-h blood glucose and insulin levels, higher C-peptide U-excretion, and higher HgbA1c in both non-diabetic and diabetic individuals [26, 27]

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Further, disruption of the melanocortin system has been linked to changes in food preference, particularly towards carbohydrate-dense and high-fat foods (161, 162)