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Regulatory bodies like the FDA have a rigorous, multi-phase process for approving new drugs that can take over a decade and cost billions of dollars

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doi: 10.1002/oby.24239 14 JingMShenglianGShijunGQuanZFangYHaifengZet al

In this regard, a burst of recent literature has focused on compounds, many of which are natural, that are capable of inhibiting/downregulating Nrf2, thus overcoming chemoresistance [81,82,83,84,85,86,87]

A comprehensive flowchart of the data selection, refinement, and utilization process is provided in Fig