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It can also restrict a persons activity and mobility, which in turn can exacerbate problems that tend to diminish health and quality of life in older adults problems such as social isolation, depression, and muscle loss, known as sarcopenia

Cycle Russian-language clinical references commonly describe courses of several weeks followed by a break rather than continuous indefinite use

Excretion Following administration of an oral [14C] sitagliptin dose to healthy subjects, approximately 100% of the administered radioactivity was eliminated in feces (13%) or urine (87%) within one week of dosing

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10.1016/j.toxlet.2016.12.010 134 ZhangP.MaD.WangY.ZhangM.QiangX.LiaoM.et al (2014)