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A combination of platinum-based drugs and fluoropyrimidine drugs is a first line

For biosimilars, the contracting structure is more complex because hospital formulary committees and prescribers control the conversion rate in ways that do not apply to small-molecule generics (where pharmacists can substitute automatically in most states)

But beneath the dramatic before-and-after photos is a darker reality for some users

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Am J Physiol 246:E334338 Candow DG, Chilibeck PD, Forbes SC (2014) Creatine supplementation and aging musculoskeletal health

This multi-system approach is part of why they are being studied for broader health benefits beyond diabetes and obesity, including heart and kidney protection