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Lower doses may still provide appetite suppression and weight loss while allowing more food intake and potentially less muscle catabolism

That's simply not sustainable the way things exist today.

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These conduits for drug delivery are characterized by hydrophobic shells and substantial aqueous reservoirs that facilitate the targeted conveyance of pharmaceuticals, nucleic acids, and proteins [204]

Nucleic Acids Res 50 , 72247234 (2022)

382 Impaired astrocytic iron homoeostasis triggers secondary neuronal iron toxicity, which together with loss of astrocytic homoeostatic support, triggers neuronal death