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In simulations of integrin binding, an increase in the glycocalyx height of 4 nm was predicted to reduce integrin bound fraction by an order of magnitude (12), while simulations of fluctuating membranes predicted that nanometer-scale height displacements of proteins can significantly alter ligand-receptor binding kinetics (13)

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In clinical trials, many patients lost a meaningful percentage of total body weight, especially when they combined the medicine with a healthy diet and regular exercise

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