For drugs escaped from the above procedure, their bioavailability is still not guaranteed because there is an additional first-pass metabolism by the liver
See are peptides safe
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Applied in respiratory disorders like infection, chronic bronchitis and pulmonary disease

HYGIENE A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES A61K38/00Medicinal preparations containing peptides Landscapes Health & Medical Sciences (AREA) Chemical & Material Sciences (AREA) Organic Chemistry (AREA) Life Sciences & Earth Sciences (AREA) General Health & Medical Sciences (AREA) Medicinal Chemistry (AREA) Animal Behavior & Ethology (AREA) Veterinary Medicine (AREA) Public Health (AREA) Pharmacology & Pharmacy (AREA) Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA) General Chemical & Material Sciences (AREA) Chemical Kinetics & Catalysis (AREA) Bioinformatics & Cheminformatics (AREA) Engineering & Computer Science (AREA) Biochemistry (AREA) Neurosurgery (AREA) Molecular Biology (AREA) Gastroenterology & Hepatology (AREA) Genetics & Genomics (AREA) Toxicology (AREA) Proteomics, Peptides & Aminoacids (AREA) Neurology (AREA) Biomedical Technology (AREA) Biophysics (AREA) Endocrinology (AREA) Heart & Thoracic Surgery (AREA) Cardiology (AREA) Zoology (AREA) Reproductive Health (AREA) Pulmonology (AREA) Psychology (AREA) Diabetes (AREA) Hematology (AREA) Dermatology (AREA) Gynecology & Obstetrics (AREA) Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA) Medicinal Preparation (AREA) Peptides Or Proteins (AREA) Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA) Description Die vorliegende Erfindung betrifft neue Anwendungsformen von synthetischen BPC(Body Protection Compound)-Peptiden, die 8 bis 15 Aminosurereste umfassen, mit einem Molekulargewicht von 900 bis 1600 Dalton, die eine organprotektive Wirkung aufweisen, Verfahren zu ihrer Herstellung und ihre Verwendung in der Diagnose und Therapie

This bypasses the digestive system completely, which means the body absorbs a much higher amount