Both HeLa and SHSY-5Y cells showed comparatively lower GGT activity upon Sp treatment, although the activities of glutamatecysteine ligase were largely comparable (Fig
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the ratio between GSH and GSSG is held in dynamic balance depending on many factors including the tissue of interest, intracellular demand for conjugation reactions, intracellular demand for reducing power, extracellular demand for reducing potential, and the complex interplay between several regulatory enzymes including glutathione peroxidase (GPx), glutathione- S -transferase (GST) and -glutamyltransferase (GGT)
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Modelling changes in glutathione homeostasis as a function of quinone redox metabolism
Research indicates it influences the FAK-paxillin signaling cascade, which is central to cell migration and tissue remodeling