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The cycling recommendation stems from lack of long-term human safety data chronic copper ion delivery beyond 6 months has not been studied in controlled trials

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In pre-clinical and in-vitro laboratory models, NAD+ research has demonstrated relevance across a remarkably wide range of cellular and molecular processes: Energy metabolism essential electron carrier in glycolysis, Krebs cycle, and oxidative phosphorylation

Rare but serious risks (like pancreatitis) will be discussed by your provider