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Clonidine is a centrally acting -adrenergic and imidazoline (I) receptor agonist that reduces central sympathetic outflow and norepinephrine release, resulting in decreased heart rate and peripheral vascular resistance

Antioxidant plays a central role in the termination of oxidative chain reactions by removing the free radical intermediates (Gholamian-Dehkordi et al., 2017)

As a result, dementia patients have a lower potential to dynamically fight free radicalsFree radicals are molecules produced when the body breaks down food or by environmental exposure to things like cigarette smoke, pollution and radiation

Vitamin B12 is an essential water-soluble nutrient also known as cobalamin

302,303,304,305 GLP-1R signaling, through PKA, inhibits this process, possibly by promoting IB stability or inhibiting its phosphorylation, thus reducing NF-B activation and nuclear translocation