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Furthermore, GLP-1 and glucose-dependent insulinotropic polypeptides have been shown to induce substance P release from sensory nerves expressing TRPV1 and TRPA1, broadening the potential pain modulation mechanisms of GLP-1 and suggesting their application in peripheral pain management 64

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11.1% of Participants Reported Using GLP-1s for More Than 18 Months 9.7% of users reported using GLP-1s for 1 month