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Researchers study KPV in preclinical work involving melanocortin related signaling and immune response pathways

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Overrepresented pathways were estimated against the background human scale metabolic model MNF (from MetaboAnalyst Mummichog package) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways for Homo sapiens to determine the relative significance of the identified pathways [50]

The 1st glutathione-interaction site, also termed glutathione-scaffold site, is rather well defined and comprises several protein areas that altogether contribute to catalysis by interacting with the glutathione moiety of GSSR 7,8,13,14,15,35 , therefore explaining the specificity for the -glutamyl moiety 9,49,50