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The chemical structure allows an extended half-life and once weekly dosing ( Ahren et al

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Semaglutide is an injectable drug that was developed to help individuals manage type 2 diabetes, but it has recently exploded in popularity for an off-label use of weight loss

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Approved by the FDA in 2017 as Ozempic for type 2 diabetes and later as Wegovy for weight management, it offers significant health benefits

37,38 A multicenter randomized controlled trial showed that patients undergoing endoscopic sleeve gastroplasty with lifestyle modifications experienced significant reductions in liver stiffness measurements compared with sham endoscopy