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Recently, a high-resolution crystal structure of phosphinic pseudopeptide inhibitor 45 (DG046) in the closed-conformation of ERAP1 was disclosed (Giastas et al., 2019b) and a mechanism for antigen peptide selection by ERAP1 presented (Giastas et al., 2019a)

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(1) This study was carried out based on the model of acute rupture of Achilles tendon in rats, while the rupture of Achilles tendon in diabetic patients may result from a long-term injury process