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The original development partner, Janssen Pharmaceuticals, has handed back the license for efinopegdutide to the original developer, Hanmi Pharmaceutical, but the license has been taken up by Merck to be developed as a once weekly treatment for NAFLD

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It is possible that compensatory mechanisms could develop that reduce efficacy with prolonged use

The proposed link between these medications and mental health effects remains controversial and not definitively established

Once dosing stops, melanocyte activity returns to genetic baseline within 1014 days, and pigmentation fades completely within 48 weeks