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Purpose Healthy volunteers are also vital to other types of studies and evaluating if new ways to detect certain conditions are safe and effective

The statistical testing strategy for the confirmatory secondary end points used a separate alpha spending function to control type I error rate at a 1-sided level of 2.5%, which aligned with the P value adjustment for the group sequential design

Lancet Oncol 21 (11): 1465-1477, 2020

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[1] Glutathione and its anti-aging and antimelanogenic effects Vitamin C: Functional cooperation between vitamin C and glutathione in providing endothelial cells with strong antioxidant defenses

A.et al (2010)