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If patients require additional treatment, they may opt for biologics or other immunomodulatory therapies such as anakinra, tocilizumab, or baricitinib [19]

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Estos frmacos retrasan el vaciamiento gstrico y modifican la motilidad intestinal, lo que puede alterar los patrones de evacuacin

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Caspase-4/5/11 can also activate the NLRP3 inflammasome, which subsequently activates caspase-1, resulting in the production and release of IL-1 and IL-18 (Sahoo et al., 2023)