-, overall negative effects
Generally, candidates fall into two primary categories: Type 2 Diabetics: Individuals requiring better glycemic control when traditional oral medications are insufficient
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Important safety considerations include the risk of hypoglycemia when tirzepatide is used in combination with insulin or sulfonylureas (requiring dose adjustments of these medications), potential thyroid C-cell tumor risk (contraindicated in patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2), and the possibility of acute pancreatitis
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Healthcare professionals should consider a baseline nutritional assessment before initiating therapy for those at higher risk, including dietary history, relevant blood tests where clinically indicated (such as full blood count, vitamin B12, vitamin D, and ferritin), and identification of risk factors for malnutrition
