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(16) demonstrated that the hepatitis B virus X protein (HBx) downregulates miR-145, leading to upregulation of CUL5, which promotes cell cycle progression (from G0/G1 to G2/M) and inhibits apoptosis

127 Thus, the Duchenne muscular dystrophy is a primary genetic astrocytopathy that impairs synaptic transmission, causes excitotoxicity and secondary neurodegeneration

Tirzepatide also carries a warning about thyroid tumors based on animal studies, though this hasnt been confirmed in humans