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While lead paint has been banned in many countries, it is still present in older buildings and homes, particularly in low-income neighborhoods

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Verma S, Leiter LA, Mazer CD, Bain SC, Buse J, Marso S, et al

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Mechanistically, TMAO induces oxidative stress and activates the ROS-TXNIP-NLRP3 inflammasome, increasing inflammatory cytokines (IL-1, IL-18), impairing endothelial nitric oxide synthase (eNOS) and nitric oxide (NO) production, and leading to endothelial dysfunction (Sun et al., 2016)

They can shift their portfolio strategies to emphasize predictability and negotiate across franchises, and undergird these agreements with real-world performance data to document the true value of each drug within larger bundles