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[DOI] [PMC free article] [PubMed] [Google Scholar] 36.Pellegrini L., Bonfio C., Chadwick J., Begum F., Skehel M., Lancaster M.A

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10.2.6 GLP-1 Receptor Antagonist 10.2.6.1 Mechanism of Action The two main incretin hormones, GIP and GLP-1, are released predominantly from L and K cells (in the proximal and distal intestine) following nutrient ingestion promoting insulin secretion, glucagon release inhibition, delaying gastric emptying, and enhancing satiety (resulting in weight control) with GLP-1 being much more effective than GIP (Van Genugten et al

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