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While semaglutide pharmacokinetics are not significantly altered in patients with hepatic impairment, the medication has not been extensively studied in patients with severe hepatic dysfunction

This article is part of the PlexusDx Education Hub science-backed guidance on GLP-1 medications, metabolic health, and precision weight management

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They may change depending on the composition and clinic

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These results are in line with previous findings indicating that inhibition of mitochondrial complex I synergizes with mitochondrial antioxidants in impairing cancer cell fitness, supporting the notion that complex I is a dominant determinant of viability (28)