UV damage, pollution, stress, a bad diet, and ageing all damage the skin
Its activity intersects two major metabolic pathways simultaneously: the NAD+ biosynthesis pathway (by consuming nicotinamide, an NAD+ precursor, NNMT competes with the NAD+ salvage pathway) and the methyl-donor pathway (by consuming SAM, NNMT reduces the availability of methyl groups for epigenetic and metabolic methylation reactions)
International Journal of Biological Macromolecules, 253 , 127554
The Evidence: Where They Differ Significantly This is the most important part of the comparison, and where the two options diverge most sharply
Clinical studies show elevated whole blood glutathione stores, enhanced natural killer cell activity, and reduced oxidative stress markers
If youre curious whether peptides could help you (gut healing, injury recovery, skin + hair, or metabolic resilience), book a discovery call with our care team to get started