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Receptor Pharmacology and Selectivity Studies Retatrutide is used as a reference compound in tri-receptor binding and activation assays, enabling researchers to compare the relative contributions of GLP-1R, GIPR, and GCGR activation to observed metabolic outcomes and benchmark tri-agonist pharmacology against dual and mono-receptor research compounds

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American College of Gastroenterology 2022 Annual Scientific Meeting Abstracts

Retatrutide is a triple receptor agonist targeting GLP-1, GIP, and glucagon receptors, distinguishing it from semaglutide and tirzepatide

2011, pp