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By working through the hypothalamic-pituitary axis, Sermorelin also maintains the body's ability to modulate GH secretion based on physiological needs - for example, endogenous GH release is increased during deep sleep, exercise, and fasting, and Sermorelin stimulation respects these natural rhythms

doi: 10.1056/NEJMoa1603827 13 MarsoSPBainSCConsoliAEliaschewitzFGJodarELeiterLAet al

The accurate stage of disease at the time of the TCGA biospecimen procurement was often not available