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A 2-week dose-escalation study (N=24) found that 25 mg/day MK-677 raised morning cortisol by approximately 19 percent and prolactin by approximately 17 percent relative to placebo [10]

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baseline spectra (buffer: 20 mM Tris pH 7.0, 150 mM NaCl) were subtracted from the averaged spectrum followed by smoothing of the data

Jim Gooch Jr., R-Providence, said he initially had concerns about the resolution because of its focus on Eastern Kentucky and the timeline for completing the study