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In 2018, MDD disease burden ranked third in the world according to the WHO, and by 2030, it is supposed to rise to the first (Malhi and Mann, 2018)
Nasal spray considerations: Typically lower bioavailability than injection, requiring somewhat higher doses Faster onset in some users due to direct CNS access More convenient and less intimidating for needle-averse individuals Requires properly calibrated spray bottles for accurate dosing Converting from injectable to nasal dosing is not straightforward
22 Together, antioxidants constitute an integrated defense against ROS (Figure 1)
Furthermore, Xue et al
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