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GIP and GLP-1 receptors are also abundantly expressed on beta-cells in the islets of Langerhans

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Non-esterified fatty acids (NEFAs), also known as free fatty acids (FFAs), are fatty acids present in the serum that are not esterified with other molecules such as glycerol or cholesterol

additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N- hexanoic-Tyr-Ile-(6)-aminohexanoic amide (dihexa), a potent cognitive enhancing molecule that proved to be very stable, to be capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, is slowly cleared from the blood compartment, and is sufficiently BBB permeable

The results for the treatment policy estimand are also presented in Table 2 and ESM Table 2 and are broadly similar to the results for the trial product estimand