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3.3.2 Leptin Produced predominantly by subcutaneous adipose tissue, leptin, a polypeptide weighing 16 kDa, arises from the ob gene situated within the chromosomal region of 7q31.3

In fact, the addition of metformin 1000 mg BID to liraglutide 1.2 mg/day was more effective than liraglutide alone in reducing body weight and BMI after 12 weeks of treatment [60]

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