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In order for class III peroxidases to produce ROS, two conditions must be satisfied: 1) ion fluxes that lead to extracellular alkalization and 2) an abundant and recyclable oxidant as electron acceptor 37

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GHK-Cu is frequently selected when the focus is on collagen biology, skin physiology, extracellular matrix remodelling or broad regenerative signalling , while BPC-157 and TB-500 are more commonly explored in experimental models centred on injury response, tissue repair and recovery mechanisms