The response in the nose is allergic rhinitis (swelling, fluid, sneezing), while activation in the lungs causes allergic asthma, fluid and mucus deep in the lungs, bronchial constriction, and coughing
The trade-off is precision versus breadth of evidence
Overview Each ml contains 1000 mcg cyanocobalamin
One 2013 review even recommends applying a vitamin C serum every 8 hours, or twice daily for the pinnacle of protection
the data collection period for each measure varies depending on measure specifications that set minimum case requirements to ensure individual measure reliability and meet the requirements of CMS quality programs, as detailed in each program's respective rules as well as on Hospital Compare or its successor website (85 FR 86202)
These applications remain areas of active scientific investigation and are intended exclusively for laboratory research